216641a
Seminar
SoSe 23: Molecular and cellular basis of neurodegenerative proteopathies.
Michael Beekes
Information for students
ATTENTION: Attendance of this seminar is a prerequisite for participation in the lab course with seminar "Self-replicating protein particles and neurodegeneration in Alzheimer's disease, Parkinson's disease and prion diseases" (216641b, c) in the winter semester. close
Comments
Content:
PD Dr. M. Beekes: BeekesM@rki.de close
- Cerebral proteopathies: Alzheimer´s disease, Parkinson´s disease, prion diseases
- Portrait of the diseases
- Protein aggregation as a common molecular key feature of different proteopathies
- Nucleation-dependent protein polymerization of amyloid-beta (Aß) and tau protein, alpha-synuclein and prion protein in Alzheimer´s, Parkinson´s and prion diseases, respectively
- Amyloid fibril formation
- Structure models and polymorphisms of amyloid fibrils
- Transmissibility of protein seeding and disease features by self-replicating Aß-, tau-, a-syn- and PrP particles
- Pathophysiology, diagnostics and therapy
PD Dr. M. Beekes: BeekesM@rki.de close